Description

4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,6-Bis(Trifluoromethyl)Pyridine is a high-value, multi-functional boronic ester derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern pharmaceutical and materials chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials industries who require the introduction of a pyridine core substituted with electron-withdrawing trifluoromethyl groups and a protected boronic acid functionality.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used to construct complex pyridine-based molecules for novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Ligand & Catalyst Development: Serves as a starting material for creating sophisticated ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Building block for organic electronic materials, such as electron-transport layers in OLEDs and semiconductors, due to the electron-deficient pyridine and trifluoromethyl groups.
• Chemical Biology Probes: Utilized in the development of molecular probes and tags for studying biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CROs/CMOs developing proprietary compounds for clients.

Basic Information

Product Name	4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,6-Bis(Trifluoromethyl)Pyridine
CAS No.	1320747-32-7
Molecular Formula	C14H16BF6NO2
Molecular Weight	355.09 g/mol
Synonyms	2,6-Bis(trifluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,6-di(trifluoromethyl)pyridine; 2,6-Di(trifluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-Pinacolatoboryl-2,6-bis(trifluoromethyl)pyridine; 4-Boronic acid, 2,6-bis(trifluoromethyl)pyridine-4-, pinacol ester
EINECS	Contact for details

Quality Control

Our 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,6-Bis(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for sensitive coupling reactions. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.