Description

Artesunate-D4 is a deuterium-labeled isotopologue of the potent antimalarial drug Artesunate, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity reference material is critical for ensuring the accuracy and reliability of pharmacokinetic and bioanalytical studies, particularly in drug development and therapeutic drug monitoring. It is an essential tool for pharmaceutical researchers, analytical laboratories, and contract research organizations (CROs) requiring precise and stable isotopic standards for mass spectrometry (LC-MS/MS).

Application

• Internal Standard for LC-MS/MS Analysis: Primary use as a stable, non-interfering internal standard for the precise quantification of Artesunate and its metabolites in biological matrices like plasma, serum, and urine.
• Pharmacokinetic and Bioavailability Studies: Enables accurate measurement of drug concentration-time profiles, supporting critical studies in drug development and clinical research.
• Drug Metabolism and Disposition (DMPK) Research: Facilitates the investigation of the absorption, distribution, metabolism, and excretion (ADME) pathways of Artesunate.
• Therapeutic Drug Monitoring (TDM): Supports the development and validation of robust assays for monitoring Artesunate levels in patients to optimize dosing regimens.
• Method Development and Validation: Serves as a key component in developing, optimizing, and validating sensitive and specific analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in impurity profiling and assay development for Artesunate-based pharmaceutical products.

Basic Information

Product Name	Artesunate-D4
CAS No.	1316753-15-7
Molecular Formula	C19H24D4O8
Molecular Weight	388.43 g/mol
Synonyms	Artesunate-d4; Dihydroartemisinin-12α-succinate-d4; (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one 12α-(succinate-d4); Dihydroartemisinin 12-α-succinate-d4; Deuterated Artesunate; Artesunate Internal Standard
EINECS	Contact for details

Quality Control

Our Artesunate-D4 is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical stability required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical results from techniques such as NMR and HPLC. We support research and development that complies with GMP/GLP principles, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the certificate of analysis. The product is light-sensitive and should be stored away from light. Keep the container tightly sealed in a dry, cool, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (LC-MS)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.