Description

(2E,11α,13E,15S,17S)-11,15-Di-o-Tetrahydropyranyl-17,20-Dimethyl-9,11,15-Trihydroxy-Prosta-2,13-Diene-1-Oic Acid-D3 Methyl Ester (Mixture Of Diastereomers) is a sophisticated, deuterated synthetic intermediate of significant value in advanced pharmaceutical research and development. This compound is specifically designed for use in the synthesis of isotopically labeled prostaglandin analogs, enabling critical pharmacokinetic and metabolic studies. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on developing novel therapeutics, particularly in areas such as inflammation, ophthalmology, and cardiovascular medicine.

Application

• Key Intermediate for Deuterated Prostaglandin Synthesis: Serves as a crucial precursor in the multi-step synthesis of isotopically labeled (deuterated) prostaglandin and prostacyclin analogs for research.
• Metabolic Tracing and ADME Studies: The incorporated deuterium (D3) label makes this compound invaluable for Absorption, Distribution, Metabolism, and Excretion (ADME) studies using techniques like LC-MS.
• Pharmaceutical Reference Standard: Used as a high-purity chemical reference standard in analytical method development and validation for quality control of related active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to develop new drug candidates targeting prostaglandin receptors.
• Process Chemistry Development: Utilized in scaling up and optimizing synthetic routes for prostaglandin-based pharmaceuticals in pilot plants and manufacturing settings.

Basic Information

Item	Detail
Product Name	(2E,11α,13E,15S,17S)-11,15-Di-o-Tetrahydropyranyl-17,20-Dimethyl-9,11,15-Trihydroxy-Prosta-2,13-Diene-1-Oic Acid-D3 Methyl Ester (Mixture Of Diastereomers)
CAS No.	1316264-00-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Prostaglandin Intermediate D3 Methyl Ester; 17,20-Dimethyl-9,11,15-trihydroxyprosta-2,13-dien-1-oic Acid-20,20,20-d3 Methyl Ester 11,15-Bis(tetrahydropyran-2-yl) Ether; Deuterated Prostaglandin F2α THP-Protected Intermediate; Methyl (5Z,13E,15S,17S)-17,20-dimethyl-9,11,15-tris[(2R)-oxan-2-yl]oxy-20,20,20-trideuterioicosa-5,13-dienoate (mixture of diastereomers); PG Intermediate CAS 1316264-00-2
EINECS	Contact for details

Quality Control

Our (2E,11α,13E,15S,17S)-11,15-Di-o-Tetrahydropyranyl-17,20-Dimethyl-9,11,15-Trihydroxy-Prosta-2,13-Diene-1-Oic Acid-D3 Methyl Ester (Mixture Of Diastereomers) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and isotopic enrichment suitable for sensitive research applications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and diastereomeric ratio are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. Allow the sealed container to reach room temperature before opening to prevent moisture condensation. Keep the material in its original packaging until use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Diastereomeric Ratio	Specified on COA
Isotopic Enrichment (D3)	≥ 98 atom % D
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.