Description

2,3-Difluoro-4-(Hydroxymethyl)Phenylboronic Acid is a specialized bifunctional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, combining a boronic acid group with a hydroxymethyl substituent on a difluorinated aromatic ring, makes it a versatile intermediate for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for applications in Suzuki-Miyaura cross-coupling reactions and medicinal chemistry.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially in the development of fluorinated drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides that benefit from the stability and bioactivity of the difluorophenyl moiety.
• Material Science: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: A pivotal reagent for forming carbon-carbon bonds to create biaryl structures, a common motif in many functional molecules.
• Medicinal Chemistry & Drug Discovery: Employed in high-throughput screening and the synthesis of compound libraries for structure-activity relationship (SAR) studies.
• Chemical Biology Probes: Useful for creating fluorescent tags, sensors, and other molecular probes due to its reactive boronic acid group.

Basic Information

Product Name	2,3-Difluoro-4-(Hydroxymethyl)Phenylboronic Acid
CAS No.	1315281-32-3
Molecular Formula	C7H7BF2O3
Molecular Weight	187.94 g/mol
Synonyms	(2,3-Difluoro-4-(hydroxymethyl)phenyl)boronic acid; 4-(Hydroxymethyl)-2,3-difluorobenzeneboronic acid; 2,3-Difluoro-4-(hydroxymethyl)benzeneboronic acid; B-[2,3-Difluoro-4-(hydroxymethyl)phenyl]boronic acid; 2,3-Difluoro-4-(hydroxymethyl)phenylboronic acid pinacol ester (common derivative); 2,3-DF-4-HMPBA (abbreviation).
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-4-(Hydroxymethyl)Phenylboronic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and commercial synthesis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and identity confirmation. Our quality system is designed to meet the stringent requirements of cGMP and ISO standards for fine chemical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.