Description

2-(Benzyloxy)-4-Bromo-1-(Trifluoromethyl)Benzene is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is valued for its unique trifluoromethyl and benzyl-protected phenol structure, which is critical for modulating the physicochemical properties of target molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries to create novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for synthesizing fluorinated aromatic compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Stille) to construct complex biaryl systems.
• Fluorine Chemistry: An important reagent for introducing the trifluoromethylphenyl moiety into molecules to improve lipophilicity, metabolic stability, and binding affinity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	2-(Benzyloxy)-4-Bromo-1-(Trifluoromethyl)Benzene
CAS No.	1314987-55-7
Molecular Formula	C14H10BrF3O
Molecular Weight	331.13 g/mol
Synonyms	4-Bromo-2-(benzyloxy)-1-(trifluoromethyl)benzene; 1-Benzyloxy-4-bromo-2-(trifluoromethyl)benzene; 2-Benzyloxy-4-bromo-alpha,alpha,α-trifluorotoluene; 4-Bromo-2-(phenylmethoxy)-1-(trifluoromethyl)benzene; 2-(Benzyloxy)-4-bromobenzotrifluoride; 1-Bromo-3-(benzyloxy)-6-(trifluoromethyl)benzene; (4-Bromo-2-(trifluoromethyl)phenoxy)methyl]benzene
EINECS	Contact for details

Quality Control

Our 2-(Benzyloxy)-4-Bromo-1-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination. Store away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.