Description

1-(5-Bromothiophen-3-Yl)-2,2,2-Trifluoroethanol is a high-value, multi-functional organofluorine building block characterized by its brominated thiophene core and trifluoroethanol side chain. This compound is essential for advanced research and development, offering a unique combination of reactivity and structural motifs for creating novel materials and active molecules. It is primarily sought after by pharmaceutical, agrochemical, and materials science industries for applications in medicinal chemistry, ligand synthesis, and the development of functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in the development of enzyme inhibitors and receptor modulators.
• Agrochemical Research: Used in the design and synthesis of new-generation pesticides and herbicides, leveraging the bioactivity of the thiophene and fluorine groups.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Functional Material Synthesis: Incorporated into polymers and small molecules to impart unique electronic, optical, or surface properties.
• Chemical Biology Probes: Utilized in the construction of molecular probes for studying biological processes and target engagement.
• Academic & Industrial R&D: A versatile reagent for exploratory chemistry in both university laboratories and corporate R&D centers.

Basic Information

Item	Detail
Product Name	1-(5-Bromothiophen-3-Yl)-2,2,2-Trifluoroethanol
CAS No.	1314894-44-4
Molecular Formula	C6H4BrF3OS
Molecular Weight	261.06 g/mol
Synonyms	5-Bromo-3-(2,2,2-trifluoro-1-hydroxyethyl)thiophene; 2,2,2-Trifluoro-1-(5-bromothiophen-3-yl)ethanol; 1-(5-Bromo-3-thienyl)-2,2,2-trifluoroethanol; 3-(2,2,2-Trifluoro-1-hydroxyethyl)-5-bromothiophene; (5-Bromothiophen-3-yl)(trifluoromethyl)methanol; α-(Trifluoromethyl)-5-bromothiophene-3-methanol
EINECS	Contact for details

Quality Control

Our 1-(5-Bromothiophen-3-Yl)-2,2,2-Trifluoroethanol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.