Description

1-(Difluoromethyl)Cyclopropanecarboxylic Acid is a high-value fluorinated cyclopropane building block, prized for its unique structural motif that imparts desirable metabolic stability and lipophilicity to target molecules. This compound serves as a critical intermediate in modern synthetic organic chemistry, enabling the efficient construction of complex pharmacophores. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoromethylcyclopropyl group can enhance biological activity and environmental stability.
• Material Science Research: Employed as a precursor for specialty polymers and advanced materials that require fluorinated components to modify surface properties or chemical resistance.
• Ligand and Catalyst Development: Serves as a sophisticated building block for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems and enzyme mechanisms.

Basic Information

Product Name	1-(Difluoromethyl)Cyclopropanecarboxylic Acid
CAS No.	1314397-71-1
Molecular Formula	C5H6F2O2
Molecular Weight	136.10 g/mol
Synonyms	1-(Difluoromethyl)cyclopropanecarboxylic acid; Cyclopropanecarboxylic acid, 1-(difluoromethyl)-; 1-(Difluoromethyl)cyclopropane-1-carboxylic acid; (1-(Difluoromethyl)cyclopropyl)formic acid; α,α-Difluoro-cyclopropaneacetic acid
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethyl)Cyclopropanecarboxylic Acid is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant industry standards for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.