Description

Alpha, ω-Disuccinimidyl Triethylene Glycol is a heterobifunctional, amine-reactive crosslinking reagent featuring a hydrophilic triethylene glycol spacer. This compound is essential for creating stable, water-soluble conjugates between biomolecules, such as proteins and peptides, while minimizing hydrophobic interactions. It is a critical tool for researchers and manufacturers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, and diagnostic assay formulation who require precise and reliable crosslinking chemistry.

Application

• Bioconjugation and Protein Labeling: Primary reagent for covalently linking proteins, antibodies, or peptides to other molecules (e.g., enzymes, fluorophores, drugs) via amine groups.
• Antibody-Drug Conjugate (ADC) Linker Chemistry: Serves as a cleavable or non-cleavable linker component to attach cytotoxic payloads to monoclonal antibodies, leveraging its hydrophilic spacer for improved solubility and pharmacokinetics.
• Diagnostic Assay Development: Used to immobilize capture antibodies or antigens onto solid supports (e.g., microplates, beads) for ELISA, lateral flow assays, and other immunoassays.
• Biomaterial and Hydrogel Fabrication: Facilitates the crosslinking of amine-containing polymers (e.g., chitosan, collagen) to create modified hydrogels and scaffolds for tissue engineering and drug delivery systems.
• Surface Functionalization: Enables the amine-reactive modification of sensor chips, nanoparticles, and other material surfaces for biosensing and biomedical device applications.
• Peptide Synthesis and Modification: Employed to introduce PEG-based spacers or crosslinks into synthetic peptides to enhance stability, solubility, or biological activity.

Basic Information

Product Name	Alpha, ω-Disuccinimidyl Triethylene Glycol
CAS No.	1314378-11-4
Molecular Formula	C18H26N2O10
Molecular Weight	430.41 g/mol
Synonyms	NHS-PEG3-NHS; Bis(N-succinimidyl) triethylene glycol ester; Disuccinimidyl triethylene glycol; Triethylene glycol bis(succinimidyl succinate); TEG-bis-NHS ester; PEG3-bis-NHS ester; 1,11-Bis[(2,5-dioxo-1-pyrrolidinyl)oxy]-3,6,9-trioxaundecane; DSC-PEG3-DSC
EINECS	Contact for details

Quality Control

Our Alpha, ω-Disuccinimidyl Triethylene Glycol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure it meets the high standards required for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.