Description

5-Fluoro-2-(Trifluoroethoxy)Phenylboronicacid is a high-value, multi-functional boronic acid derivative used as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and trifluoroethoxy substituents, makes it an essential reagent for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for applications in cross-coupling reactions, such as the Suzuki-Miyaura reaction, to create novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the fluorine and trifluoroethoxy groups enhance biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: Acts as a versatile boronic acid partner for palladium-catalyzed cross-coupling reactions to form biaryl and heterobiaryl structures, a cornerstone of modern medicinal chemistry.
• Chemical Biology & Probe Development: Utilized in the creation of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and libraries for high-throughput screening.

Basic Information

Product Name	5-Fluoro-2-(Trifluoroethoxy)Phenylboronicacid
CAS No.	1313760-94-9
Molecular Formula	C8H7BF4O3
Molecular Weight	238.95 g/mol
Synonyms	[5-Fluoro-2-(trifluoromethoxy)phenyl]boronic acid; (5-Fluoro-2-(trifluoromethoxy)phenyl)boronic acid; 2-Trifluoromethoxy-5-fluorophenylboronic acid; 5-Fluoro-2-trifluoromethoxyphenylboronic Acid; Boronic acid, B-[5-fluoro-2-(trifluoromethoxy)phenyl]-; 1313760-94-9; AKOS025311065; FT-0698391.
EINECS	Contact for details

Quality Control

Every batch of 5-Fluoro-2-(Trifluoroethoxy)Phenylboronicacid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.