Description

3,5-Difluoro-4-Morpholinophenylboronic Acid Pinacol Ester is a high-value, synthetically versatile organoboron building block. This compound is critical for enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are foundational to modern pharmaceutical and advanced materials research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates containing difluorophenyl and morpholino motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific aryl coupling.
• Material Science Research: Employed in the creation of organic electronic materials, including OLEDs and semiconductors, where precise molecular structure is paramount.
• Cross-Coupling Reactions: Serves as a reliable boron reagent in Suzuki-Miyaura couplings for forming carbon-carbon bonds under mild conditions.
• Ligand and Catalyst Development: Utilized as a precursor for synthesizing novel ligands and organometallic catalysts.
• Chemical Biology Probes: Acts as a synthetic handle for creating labeled molecules and probes for biological target identification.

Basic Information

Product Name	3,5-Difluoro-4-Morpholinophenylboronic Acid Pinacol Ester
CAS No.	1313738-69-0
Molecular Formula	C₁₆H₂₂BF₂NO₃
Molecular Weight	325.16 g/mol
Synonyms	4-Morpholino-3,5-difluorophenylboronic acid pinacol ester; 3,5-Difluoro-4-morpholinobenzeneboronic acid pinacol ester; (3,5-Difluoro-4-morpholinophenyl)boronic acid pinacol ester; 2-(3,5-Difluoro-4-morpholinophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; B-(3,5-Difluoro-4-morpholinophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; CAS 1313738-69-0; DifluoromorpholinophenylBPin
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-Morpholinophenylboronic Acid Pinacol Ester is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.