Description

4-Chlorocarbonyl-3-Fluorophenylboronic Acid is a high-value bifunctional organic intermediate that combines a boronic acid group with an acid chloride moiety. This unique structure makes it a critical building block for the synthesis of complex molecules, particularly in pharmaceutical and advanced material research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel compounds via Suzuki-Miyaura cross-coupling and subsequent amide bond formation.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorinated compounds and kinase inhibitors.
• Agrochemical Synthesis: Used to create novel, fluorinated herbicides, fungicides, and pesticides with enhanced biological activity.
• Material Science: Building block for organic electronic materials, such as polymers and small molecules for OLEDs and OFETs.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing sophisticated boronic acid-based ligands for catalysis.
• Bioconjugation and Probe Synthesis: Utilized in creating fluorescent probes, biomarkers, and other tools for biochemical research.
• Custom Synthesis and Contract Manufacturing: Essential for research organizations and CDMOs engaged in custom synthesis projects requiring specific fluorinated boronic acid derivatives.

Basic Information

Product Name	4-Chlorocarbonyl-3-Fluorophenylboronic Acid
CAS No.	1313712-87-6
Molecular Formula	C7H5BClFO3
Molecular Weight	201.38 g/mol
Synonyms	3-Fluoro-4-(chlorocarbonyl)phenylboronic Acid; (4-Chlorocarbonyl-3-fluorophenyl)boronic Acid; 4-(Chloroformyl)-3-fluorobenzeneboronic Acid; 3-Fluoro-4-carboxyphenylboronic Acid Chloride; 4-Boronobenzoic Acid, 3-Fluoro-, Chloride; 4-(Chlorocarbonyl)-3-fluorobenzeneboronic Acid
EINECS	Contact for details

Quality Control

Our 4-Chlorocarbonyl-3-Fluorophenylboronic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of research and development, adhering to relevant industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis of the acid chloride group. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.