Description

(R)-2-(Benzyloxycarbonylamino)-6-Guanidinohexanoic Acid CAS NO 1313054-55-5 is a high-purity, non-natural amino acid derivative featuring a protected N-terminus (Cbz) and a guanidino functional group on the side chain. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, enabling precise control over molecular structure and bioactivity. It is primarily utilized by pharmaceutical R&D and process development teams for applications in drug discovery, particularly in the development of protease inhibitors, cell-penetrating peptides, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the solid-phase and solution-phase synthesis of therapeutic peptides targeting various diseases.
• Protease Inhibitor Development: Used to incorporate arginine-like motifs for creating potent and selective inhibitors of serine and cysteine proteases.
• Cell-Penetrating Peptide (CPP) Synthesis: Serves as a building block to introduce guanidinium groups, which are essential for the membrane translocation properties of CPPs.
• Bioconjugation & Labeling: The reactive functional groups allow for site-specific modification and labeling of peptides for diagnostic or research purposes.
• Chemical Biology Research: Employed in the study of protein-protein interactions and signal transduction pathways using designed peptide probes.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	(R)-2-(Benzyloxycarbonylamino)-6-Guanidinohexanoic Acid
CAS No.	1313054-55-5
Molecular Formula	C15H22N4O4
Molecular Weight	322.36 g/mol
Synonyms	Nα-Cbz-Nω-guanidino-L-arginine; Nα-Cbz-Nω-Guanidino-L-Arg-OH; Z-Arg(Nω-Guanidino)-OH; (R)-2-(((Benzyloxy)carbonyl)amino)-6-guanidinohexanoic acid; Nα-Carbobenzoxy-Nω-guanidino-L-arginine; Cbz-Arg(Nω-Guanidino); (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-guanidinohexanoic acid (Fmoc-analogue reference); L-Arg(Cbz, Nω-Guanidino)
EINECS	Contact for details

Quality Control

Our (R)-2-(Benzyloxycarbonylamino)-6-Guanidinohexanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with exacting standards for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity (HPLC), and specific impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.