Description

Folate-Peg3-Azide is a high-purity, functionalized folate derivative designed for advanced bioconjugation and click chemistry applications. This compound is engineered to enable the precise and efficient attachment of folic acid targeting moieties to a wide array of biomolecules, nanoparticles, and surfaces. It is an essential building block for researchers and manufacturers in the fields of targeted drug delivery, diagnostic probe development, and advanced material science, where site-specific labeling and controlled functionalization are critical.

Application

• Targeted Drug Delivery Systems: Conjugation to nanoparticles, liposomes, or antibody-drug conjugates (ADCs) for folate receptor-mediated cancer therapy.
• Diagnostic Imaging Agents: Site-specific labeling of probes for fluorescence, PET, or SPECT imaging to target folate receptor-positive cells.
• Bioconjugation & Click Chemistry: Key reagent for copper-catalyzed or strain-promoted azide-alkyne cycloaddition (SPAAC) with alkyne-functionalized molecules.
• Surface Functionalization: Modification of biosensor surfaces, microarray chips, or polymeric materials to introduce folate targeting capability.
• Chemical Biology Research: Tool compound for studying folate receptor biology, cellular uptake mechanisms, and intracellular trafficking.
• Precision Medicine & Theranostics: Development of combined therapeutic and diagnostic (theranostic) platforms.

Basic Information

Product Name	Folate-Peg3-Azide
CAS No.	1313026-32-2
Molecular Formula	C29H38N10O8
Molecular Weight	654.68 g/mol
Synonyms	Folic Acid-PEG3-Azide; Nα-(4-(((2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzoyl)-N2-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-L-glutamine; Azido-PEG3-Folate; 6-((((2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzoyl)amino)-N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-L-glutamine; Folate-PEG3-N3; FA-PEG3-Azide
EINECS	Contact for details

Quality Control

Our Folate-Peg3-Azide is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry, to confirm identity, purity, and functional integrity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and cGMP-grade production for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.