Description

1',4-Bis(T-Butyl)-1,2-Bis(Diphenylphosphino)-3'-(Di-I-Propylphosphino)Ferrocene, 98% Hiersophos-1 CAS NO 1313012-94-0 is a high-purity, chiral ferrocenyl diphosphine ligand designed for advanced asymmetric catalysis. This compound matters because it offers exceptional stereoselectivity and tunable steric bulk, enabling highly efficient and selective transformations in fine chemical synthesis. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel synthetic routes to chiral intermediates and active ingredients.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, critical for producing single-enantiomer pharmaceutical actives.
• Cross-Coupling Reactions: Facilitates challenging C-C and C-X bond formations under mild conditions with high functional group tolerance.
• Hydroformylation: Enables regioselective and asymmetric hydroformylation of alkenes to produce valuable chiral aldehydes.
• Pharmaceutical Intermediate Synthesis: Key catalyst component in the synthesis of complex, chiral drug molecules, including β-lactam antibiotics and cardiovascular agents.
• Agrochemical Production: Used in the manufacture of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable tool for methodology development and exploring new catalytic cycles in organometallic chemistry.
• Fine Chemical Manufacturing: Applied in the production of specialty flavors, fragrances, and advanced materials requiring precise stereochemical control.

Basic Information

Product Name	1',4-Bis(T-Butyl)-1,2-Bis(Diphenylphosphino)-3'-(Di-I-Propylphosphino)Ferrocene, 98% Hiersophos-1
CAS No.	1313012-94-0
Molecular Formula	C49H58FeP3
Molecular Weight	780.76 g/mol
Synonyms	Hiersophos-1; (R)-1',4-Bis(tert-butyl)-1,2-bis(diphenylphosphino)-3'-(diisopropylphosphino)ferrocene; Josiphos-type ligand SL-J009-1; Chiral ferrocenyl phosphine ligand; tBu-Josiphos derivative; Asymmetric hydrogenation ligand SL-J009-1; (R)-1-[1',4-Bis(tert-butyl)-3'-(diisopropylphosphino)ferrocenyl]-1,2-bis(diphenylphosphino)ethane (common misnomer); Fc(PPh2)(PtBu2)(P(i-Pr)2)
EINECS	Contact for details

Quality Control

Our 1',4-Bis(T-Butyl)-1,2-Bis(Diphenylphosphino)-3'-(Di-I-Propylphosphino)Ferrocene is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high catalytic performance. Every lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and chiral analysis to verify enantiomeric purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) at 2-8°C. The material is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or ambient light should be avoided to maintain catalytic activity. The storage area should be cool, dry, and well-ventilated.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline powder or solid
Assay (HPLC)	≥ 98.0%
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Specific Rotation [α]D20	Contact for details
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm
Solubility	Soluble in common organic solvents (Toluene, DCM, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.