Description

Boronic Acid, B-[4-[[4-[(E)-[1-[(4-Fluorophenyl)Methyl]-2,5-Dioxo-3-Pyrrolidinylidene]Methyl]Phenoxy]Methyl]Phenyl]- is a sophisticated, high-purity organic building block featuring a maleimide-linked boronic acid moiety. This compound matters as a critical intermediate for the synthesis of advanced pharmaceutical agents, particularly in the development of targeted therapies and antibody-drug conjugates (ADCs). It is primarily needed by research institutions and pharmaceutical companies engaged in cutting-edge drug discovery and bioconjugation chemistry.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel small-molecule drugs and targeted cancer therapies.
• Bioconjugation Reagent: Used in the development of Antibody-Drug Conjugates (ADCs) and other biopharmaceuticals, leveraging the maleimide group for thiol coupling and the boronic acid for further functionalization.
• Proteolysis-Targeting Chimera (PROTAC) Development: Serves as a versatile linker component in the design of heterobifunctional molecules for targeted protein degradation.
• Chemical Biology Research: Employed as a tool compound for studying enzyme inhibition, protein labeling, and cellular signaling pathways.
• Material Science: Potential precursor for advanced polymeric materials and sensors due to its reactive boronic acid functionality.
• Organic Synthesis: A versatile reagent for Suzuki-Miyaura cross-coupling reactions to create complex biaryl structures central to many active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Boronic Acid, B-[4-[[4-[(E)-[1-[(4-Fluorophenyl)Methyl]-2,5-Dioxo-3-Pyrrolidinylidene]Methyl]Phenoxy]Methyl]Phenyl]-
CAS No.	1312201-54-9
Molecular Formula	C25H19BFNO4
Molecular Weight	427.24 g/mol
Synonyms	[4-[[4-[(E)-[1-[(4-Fluorophenyl)methyl]-2,5-dioxo-3-pyrrolidinylidene]methyl]phenoxy]methyl]phenyl]boronic acid; (4-((4-((E)-1-(4-Fluorobenzyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3(2H)-ylidene)methyl)phenoxy)methyl)phenyl)boronic acid; B-[4-[[4-[(1E)-1-[1-[(4-Fluorophenyl)methyl]-2,5-dioxo-3-pyrrolidinylidene]methyl]phenoxy]methyl]phenyl]boronic acid; Maleimide-PEG1-Benzyl-Boronic Acid (analog); 4-((4-((E)-1-(4-Fluorobenzyl)-3-(hydroxyboraneylidene)-2,5-dioxopyrrol-3-ium-3-yl)methyl)phenoxy)methyl)benzen-1-boronic acid; Boronic acid derivative of N-(4-fluorobenzyl)maleimide.
EINECS	Contact for details

Quality Control

Our Boronic Acid, B-[4-[[4-[(E)-[1-[(4-Fluorophenyl)Methyl]-2,5-Dioxo-3-Pyrrolidinylidene]Methyl]Phenoxy]Methyl]Phenyl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity suitable for sensitive pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.