Description

n-Fmoc-2-Amino-2-(2-Propenyl)-4-Pentenoic Acid is a specialized, non-proteinogenic amino acid derivative designed for advanced peptide synthesis and medicinal chemistry research. This compound is engineered to introduce unique structural motifs and reactive handles, such as the two terminal alkenes, enabling further chemical modifications like cross-metathesis or click chemistry. It is an essential building block for pharmaceutical R&D teams, academic researchers, and fine chemical manufacturers developing novel peptide-based therapeutics, drug conjugates, and chemical probes. The high purity and consistent quality of this Fmoc-protected amino acid are critical for ensuring successful and reproducible solid-phase peptide synthesis (SPPS) outcomes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected building block for the automated synthesis of peptides containing non-natural amino acid residues.
• Medicinal Chemistry & Drug Discovery: For the design and synthesis of novel peptide-based drug candidates, including constrained peptides and peptidomimetics.
• Chemical Biology & Bioconjugation: Utilizes the pendant alkenyl groups for site-specific post-synthetic modifications via thiol-ene or olefin metathesis reactions to attach labels, polymers, or other functional groups.
• Library Synthesis for Screening: Used in combinatorial chemistry to create diverse libraries of modified peptides for high-throughput screening against biological targets.
• Research on Structure-Activity Relationships (SAR): Incorporation into peptide sequences to study the effect of side-chain rigidity and hydrophobicity on biological activity and stability.
• Development of Peptide Materials: A monomer for constructing synthetic peptides with tailored physical properties for material science applications.

Basic Information

Product Name	n-Fmoc-2-Amino-2-(2-Propenyl)-4-Pentenoic Acid
CAS No.	1311992-97-8
Molecular Formula	C24H25NO4
Molecular Weight	391.46 g/mol
Synonyms	Fmoc-2-Amino-2-(2-propenyl)-4-pentenoic acid; 2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino-2-(prop-2-en-1-yl)pent-4-enoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-(prop-2-en-1-yl)-4-pentenoic acid; Fmoc-2-(2-Propenyl)-4-pentenoic acid; Fmoc-Dienylglycine; Fmoc-2-Allyl-4-pentenoic acid (common name); N-Fmoc-2-amino-2-(allyl)-4-pentenoic acid
EINECS	Contact for details

Quality Control

Our n-Fmoc-2-Amino-2-(2-Propenyl)-4-Pentenoic Acid is manufactured under strict quality management systems to ensure the high purity and consistency required for sensitive synthetic applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. We provide full traceability and a detailed Certificate of Analysis (COA) with every shipment, which includes data on assay, chiral purity, and specified impurities. Our quality commitment supports compliance with the stringent standards expected in pharmaceutical R&D and fine chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.