Description

2-Propanesulfinamide, n-[1-(2-Fluoro-5-Nitrophenyl)Ethylidene]-2-Methyl- is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound matters for its role as a critical chiral building block, enabling the development of novel therapeutic agents with high stereochemical purity. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new drugs, particularly in areas requiring sophisticated organic synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel APIs, especially for central nervous system (CNS) and oncology targets.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce high enantioselectivity.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in drug discovery and lead optimization programs.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for the production of clinical trial materials and commercial drug substances.
• Academic Research: Employed in university and institutional labs for methodological studies in organic and organosulfur chemistry.

Basic Information

Product Name	2-Propanesulfinamide, n-[1-(2-Fluoro-5-Nitrophenyl)Ethylidene]-2-Methyl-
CAS No.	1311388-01-8
Molecular Formula	C12H15FN2O3S
Molecular Weight	286.32 g/mol
Synonyms	N-[(1E)-1-(2-Fluoro-5-nitrophenyl)ethylidene]-2-methylpropane-2-sulfinamide; (E)-N-(1-(2-Fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide; 2-Methyl-N-[(1E)-1-(2-fluoro-5-nitrophenyl)ethylidene]propane-2-sulfinamide; tert-Butanesulfinamide, N-[(1E)-1-(2-fluoro-5-nitrophenyl)ethylidene]-; (E)-2-Methyl-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)propane-2-sulfinamide; N-(1-(2-Fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide; 1311388-01-8; 2-Propanesulfinamide, N-[1-(2-fluoro-5-nitrophenyl)ethylidene]-2-methyl-
EINECS	Contact for details

Quality Control

Our 2-Propanesulfinamide, n-[1-(2-Fluoro-5-Nitrophenyl)Ethylidene]-2-Methyl- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure compliance with stringent pharmaceutical intermediate standards. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.