Description

Cbz-L-β-Homovaline Methyl Ester is a protected amino acid derivative widely used as a key chiral building block in advanced organic synthesis. This high-purity intermediate is essential for constructing complex peptide mimetics and bioactive molecules with precise stereochemistry. It is particularly valuable for pharmaceutical research and development, serving the needs of medicinal chemists and process development scientists in drug discovery programs.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of novel peptide-based drug candidates and protease inhibitors.
• Peptidomimetics Research: Used to incorporate non-natural amino acid residues into peptide chains to enhance metabolic stability and binding affinity.
• Chemical Biology Probes: Serves as a building block for creating labeled or modified peptides used in studying protein-protein interactions and enzyme mechanisms.
• Process Chemistry: Employed in the scalable synthesis of active pharmaceutical ingredients (APIs) requiring specific β-homo amino acid frameworks.
• Academic Research: Utilized in university and institutional labs for methodological development in asymmetric synthesis and peptide chemistry.

Basic Information

Product Name	Cbz-L-β-Homovaline Methyl Ester
CAS No.	1311255-15-8
Molecular Formula	C16H23NO4
Molecular Weight	293.36 g/mol
Synonyms	N-Carbobenzoxy-L-β-homovaline methyl ester; (S)-Methyl 2-(((benzyloxy)carbonyl)amino)-4-methylpentanoate; Cbz-β-homo-L-Val-OMe; Benzyl N-[(2S)-1-methoxy-4-methyl-1-oxopentan-2-yl]carbamate; Nα-Cbz-L-β-homovaline methyl ester; L-β-Homovaline, N-carbobenzoxy-, methyl ester; Methyl N-carbobenzoxy-L-β-homovaline
EINECS	Contact for details

Quality Control

Our Cbz-L-β-Homovaline Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. A Certificate of Analysis (COA) detailing identity, purity, and specific impurities is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.