Description

(5R)-5-(Trifluoromethyl)Pyrrolidin-2-One CAS NO 1311255-07-8 is a high-value, chiral pyrrolidinone derivative distinguished by its trifluoromethyl group. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block in modern synthetic chemistry. It is primarily required by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of small molecule drugs, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides requiring fluorinated motifs for enhanced activity and stability.
• Ligand and Catalyst Development: Precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Used in the synthesis of fluorinated polymers and advanced materials with unique surface properties.
• Academic & Contract Research: Essential for medicinal chemistry programs and process development in academic and CRO/CMO settings.

Basic Information

Product Name	(5R)-5-(Trifluoromethyl)Pyrrolidin-2-One
CAS No.	1311255-07-8
Molecular Formula	C5H6F3NO
Molecular Weight	153.10 g/mol
Synonyms	(R)-5-(Trifluoromethyl)-2-pyrrolidinone; (5R)-5-(Trifluoromethyl)-2-pyrrolidinone; (R)-5-Trifluoromethyl-2-pyrrolidinone; 2-Pyrrolidinone, 5-(trifluoromethyl)-, (5R)-; (R)-5-Trifluoromethylpyrrolidin-2-one; (R)-α-(Trifluoromethyl)-γ-butyrolactam; (R)-5-Trifluoromethyl-2-oxopyrrolidine
EINECS	Contact for details

Quality Control

Our (5R)-5-(Trifluoromethyl)Pyrrolidin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with customer specifications and industry standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.