Description

2-(4-(Difluoromethyl)-3-Methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is a high-purity boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis. CAS No. 1310949-77-9.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing difluoromethyl and methoxy-substituted aromatic systems.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific aryl-boronate functionalities.
• Material Science Research: Serves as a monomer or building block for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a stable, air-handleable boronate reagent for palladium-catalyzed carbon-carbon bond formation with aryl halides.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Useful for synthesizing tagged molecules and probes for studying biological processes and target engagement.

Basic Information

Item	Details
Product Name	2-(4-(Difluoromethyl)-3-Methoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1310949-77-9
Molecular Formula	C14H19BF2O3
Molecular Weight	284.11 g/mol
Synonyms	(4-(Difluoromethyl)-3-methoxyphenyl)boronic acid pinacol ester; (3-Methoxy-4-(difluoromethyl)phenyl)boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-[3-methoxy-4-(difluoromethyl)phenyl]-1,3,2-dioxaborolane; Pinacol [3-methoxy-4-(difluoromethyl)phenyl]boronate; 1310949-77-9; Boronic acid, B-[4-(difluoromethyl)-3-methoxyphenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 2-(4-(Difluoromethyl)-3-Methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment and are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged use or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.