Description

Azido-Peg3-Ss-Peg3-Azide is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring terminal azide groups and a central disulfide (SS) bond. This compound is engineered to enable controlled bioconjugation and the construction of stimuli-responsive molecular architectures. It is a critical reagent for researchers and developers in the fields of advanced drug delivery, bioconjugation chemistry, and materials science. The product is supplied under the CAS registry number 1310827-27-0.

Application

• Bioconjugation and ADC Development: Used for site-specific conjugation of antibodies, proteins, or peptides to drugs, fluorophores, or other payloads via click chemistry (e.g., copper-catalyzed or strain-promoted azide-alkyne cycloaddition).
• Stimuli-Responsive Linker: The central disulfide bond is cleavable under reducing conditions (e.g., in the intracellular environment), making it ideal for designing redox-sensitive drug delivery systems and prodrugs.
• PEGylation and Hydrophilicity Enhancement: The triethylene glycol (PEG3) spacers improve solubility, reduce immunogenicity, and prolong circulation time of conjugated biomolecules.
• Polymer and Materials Science: Serves as a versatile building block for synthesizing functional hydrogels, smart polymers, and surface coatings with cleavable properties.
• Chemical Biology Probes: Facilitates the creation of activity-based probes or affinity labels for studying protein function and interactions.
• Nanoparticle Functionalization: Enables the attachment of targeting ligands or stealth coatings to liposomes, dendrimers, and other nanocarriers.

Basic Information

Product Name	Azido-Peg3-Ss-Peg3-Azide
CAS No.	1310827-27-0
Molecular Formula	C18H34N6O6S2
Molecular Weight	494.62 g/mol
Synonyms	1,11-Bis(azido)-3,6,9-trioxa-12-thiaundecane; 3,6,9,12-Tetraoxa-15,16-dithia-1,14-diazatetradecan-1,14-diazide; Azido-PEG3-SS-PEG3-azide; N3-PEG3-SS-PEG3-N3; Bis(azido-PEG3) disulfide; Heterobifunctional PEG crosslinker, azide and disulfide; 1-Azido-2,5,8,11-tetraoxa-14,15-dithia-16-azidohexadecane
EINECS	Contact for details

Quality Control

Every batch of Azido-Peg3-Ss-Peg3-Azide is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We ensure high purity and batch-to-batch consistency through rigorous testing, including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and relevant specifications. Our quality commitment supports applications in GMP-grade research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.