Description

(R)-Fmoc-2-Amino-3-Dodecylsulfanyl-Propionic Acid is a specialized, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is engineered to introduce a lipophilic, long-chain alkylthio side chain, which is critical for modulating the hydrophobicity, membrane permeability, and structural stability of synthetic peptides. It is an essential building block for researchers and manufacturers in pharmaceutical development, particularly for creating novel peptide-based therapeutics, diagnostic agents, and biochemical probes. The CAS number for this compound is 1310682-09-7.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy, enabling the controlled incorporation of a dodecylthioether functional group into peptide chains.
• Lipopeptide Development: Used to synthesize lipopeptides with enhanced cell-penetrating abilities and improved pharmacokinetic properties for drug delivery applications.
• Membrane Protein Mimetics: Essential for constructing peptides that mimic or interact with lipid bilayers and membrane proteins in structural biology studies.
• Antimicrobial Peptide (AMP) Research: Facilitates the development of novel AMPs with modified hydrophobicity to target specific bacterial membranes.
• Bioconjugation and Probe Synthesis: Serves as a precursor for creating fluorescent or affinity-labeled peptide probes used in cellular imaging and target identification.
• Peptidomimetic Libraries: A valuable component in combinatorial chemistry for generating diverse libraries of peptidomimetics for high-throughput screening.

Basic Information

Product Name	(R)-Fmoc-2-Amino-3-Dodecylsulfanyl-Propionic Acid
CAS No.	1310682-09-7
Molecular Formula	C30H41NO4S
Molecular Weight	511.72 g/mol
Synonyms	Fmoc-S-dodecyl-L-cysteine; (R)-Fmoc-Cys(S-Dodecyl)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-dodecyl-L-cysteine; Fmoc-L-Cys(S-Dodecyl)-OH; Fmoc-Cys(S-C12H25)-OH; Nα-Fmoc-S-dodecyl-L-cysteine; (2R)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(dodecylsulfanyl)propanoic acid
EINECS	Contact for details

Quality Control

Our (R)-Fmoc-2-Amino-3-Dodecylsulfanyl-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.