Description

(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3,3-Dimethylpent-4-Enoic Acid is a high-purity, non-natural amino acid derivative featuring a fluorenylmethyloxycarbonyl (Fmoc) protecting group on the amine and a unique, sterically hindered 3,3-dimethylpent-4-enoic acid side chain. This compound is a critical building block for the solid-phase peptide synthesis (SPPS) of peptides and peptidomimetics with enhanced conformational stability and lipophilicity. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced peptide drug discovery, medicinal chemistry, and the development of novel therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of custom peptides with tailored properties.
• Peptidomimetic Drug Discovery: Incorporation into peptide backbones to improve metabolic stability, membrane permeability, and target binding affinity.
• Medicinal Chemistry & SAR Studies: Used to explore structure-activity relationships by introducing a bulky, hydrophobic side chain into lead peptide sequences.
• Bioconjugation & Chemical Biology: Serves as a specialized linker or functional handle for labeling peptides or creating peptide-based probes.
• Pharmaceutical Intermediate: A high-value raw material in the synthesis of complex peptide-based active pharmaceutical ingredients (APIs).
• Academic & Industrial Research: Essential for fundamental research in biochemistry, protein engineering, and material science involving peptide design.

Basic Information

Item	Details
Product Name	(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3,3-Dimethylpent-4-Enoic Acid
CAS No.	1310680-41-1
Molecular Formula	C24H25NO4
Molecular Weight	391.46 g/mol
Synonyms	Fmoc-3,3-dimethylpent-4-enoic acid; Fmoc-Dmpene-OH; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3,3-dimethylpent-4-enoic acid; Fmoc-(S)-2-amino-3,3-dimethylpent-4-enoic acid; Fmoc-δ-methyl-norvaline derivative; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,3-dimethyl-L-pent-4-enoic acid; Fmoc-L-3,3-dimethylpent-4-enoic acid; Fmoc-Dmp(ene)-OH
EINECS	Contact for details

Quality Control

Our (2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3,3-Dimethylpent-4-Enoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive spectroscopic identification (NMR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade and cGMP standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress. For long-term storage under inert atmosphere, please contact us.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.