Description

(R,S)-Fmoc-β, β-Dimethyl-Phenylalanine is a non-natural, sterically hindered amino acid derivative protected with a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), where its unique dimethyl-substituted β-carbon introduces conformational constraints to modulate peptide stability and biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and bioactive probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of complex peptides.
• Peptidomimetic Drug Discovery: Incorporation into peptide backbones to enhance metabolic stability, receptor selectivity, and membrane permeability.
• Conformationally Restricted Peptides: Used to study structure-activity relationships (SAR) by introducing local rigidity into peptide chains.
• Chemical Biology Probes: Synthesis of labeled or modified peptides for studying protein-protein interactions and enzyme mechanisms.
• Academic & Industrial Research: A valuable reagent for medicinal chemistry and biochemistry research programs.
• API Intermediate Development: Potential use in the synthetic pathway of peptide-based Active Pharmaceutical Ingredients (APIs).

Basic Information

Item	Detail
Product Name	(R,S)-Fmoc-β, β-Dimethyl-Phenylalanine
CAS No.	1310680-19-3
Molecular Formula	C26H25NO4
Molecular Weight	415.48 g/mol
Synonyms	Fmoc-β,β-dimethyl-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,3-dimethyl-L-phenylalanine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3,3-dimethyl-3-phenylpropanoic acid; Fmoc-Dmp-OH; Fmoc-3,3-dimethylphenylalanine; N-Fmoc-3,3-dimethyl-L-phenylalanine; (R,S)-Fmoc-β,β-Dimethylphenylalanine; Nα-Fmoc-β,β-dimethyl-L-phenylalanine
EINECS	Contact for details

Quality Control

Our (R,S)-Fmoc-β, β-Dimethyl-Phenylalanine is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure specification compliance for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.