Description

3-Formyl-4-(trifluoromethoxy)phenylboronic acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a formyl group and a trifluoromethoxy substituent on the aromatic ring, makes it an exceptionally versatile reagent for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable intermediates for Suzuki-Miyaura cross-coupling reactions and other catalytic transformations.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides, leveraging the metabolic stability imparted by the trifluoromethoxy group.
• Liquid Crystal & OLED Materials: Serves as a building block for advanced electronic materials, where its structural motifs contribute to desired electronic and optical properties.
• Suzuki-Miyaura Cross-Coupling: Primarily employed as a boronic acid coupling partner to introduce the formyl- and trifluoromethoxy-substituted phenyl moiety into biaryl systems.
• Metal-Organic Framework (MOF) Construction: Utilized as a linker molecule in the design of porous coordination polymers for gas storage and catalysis.
• Chemical Biology & Proteomics: Acts as a handle for bioconjugation and the development of chemical probes due to the reactivity of the aldehyde group.

Basic Information

Product Name	3-Formyl-4-(trifluoromethoxy)phenylboronic Acid
CAS No.	1310383-91-5
Molecular Formula	C8H6BF3O4
Molecular Weight	233.94 g/mol
Synonyms	4-Formyl-3-(trifluoromethoxy)benzeneboronic acid; [4-Formyl-3-(trifluoromethoxy)phenyl]boronic acid; 3-(Trifluoromethoxy)-4-formylbenzeneboronic acid; 4-Borono-2-(trifluoromethoxy)benzaldehyde; 2-(Trifluoromethoxy)-4-formylphenylboronic acid; 3-Carbaldehyde-4-(trifluoromethoxy)benzeneboronic acid; 3-Formyl-4-(trifluoromethoxy)benzeneboronic acid
EINECS	Contact for details

Quality Control

Every batch of 3-Formyl-4-(trifluoromethoxy)phenylboronic acid is manufactured and tested under strict quality management systems. We guarantee high lot-to-lot consistency and purity to meet the exacting standards of research and commercial-scale synthesis. Our products undergo rigorous quality testing, including HPLC, NMR, and elemental analysis, to ensure compliance with customer specifications. Certificates of Analysis (COA) detailing all critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent oxidation and hydrolysis. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.