Description

Cbz-n-Amido-Peg3-Acid is a high-purity, synthetic organic compound featuring a carboxybenzyl (Cbz) protecting group linked to a carboxylic acid via a triethylene glycol (PEG3) spacer. This molecular architecture makes it a versatile and valuable building block for advanced chemical synthesis, particularly in the development of complex molecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical and bioconjugation sectors who require precise and reliable intermediates for constructing peptide mimetics, antibody-drug conjugates (ADCs), and other sophisticated therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs) and prodrugs.
• Peptide & Protein Modification: Used to introduce hydrophilic PEG linkers and functional handles into peptides and proteins for improved solubility and bio-conjugation.
• Antibody-Drug Conjugate (ADC) Development: Serves as a crucial component for constructing the chemical linkers that connect cytotoxic drugs to monoclonal antibodies.
• Bioconjugation Chemistry: Enables the site-specific attachment of drugs, dyes, or other molecules to biological targets via its reactive carboxylic acid group.
• Polymer & Material Science: Acts as a functional monomer or cross-linking agent for creating specialized polymers with tailored properties.
• Research & Development: An essential reagent in medicinal chemistry for exploring new chemical entities and structure-activity relationships (SAR).

Basic Information

Item	Details
Product Name	Cbz-n-Amido-Peg3-Acid
CAS No.	1310327-18-4
Molecular Formula	C19H27NO7
Molecular Weight	381.42 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]-3,6,9-trioxa-12-azadodecan-12-oic acid; Fmoc-N-amido-PEG3-acid; Carboxybenzyl-PEG3-acid; Cbz-NH-PEG3-COOH; N-Cbz-3,6,9-trioxa-12-azadodecanoic acid; Benzyl N-(11-carboxy-3,6,9-trioxaundecyl)carbamate; PEG3-Cbz-acid
EINECS	Contact for details

Quality Control

Our Cbz-n-Amido-Peg3-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.