Description

1-Bromo-3-n-Butyloxy-4-Fluorobenzene is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. This compound is valued for its unique combination of bromine and fluorine substituents, which allow for selective cross-coupling reactions and further functionalization. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic cores for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluorine atom improves biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials due to its halogenated structure.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Heck couplings, enabling the construction of complex biaryl systems.
• Chemical Library Development: Employed in medicinal and combinatorial chemistry for the generation of diverse compound libraries for high-throughput screening.

Basic Information

Product Name	1-Bromo-3-n-Butyloxy-4-Fluorobenzene
CAS No.	1309933-37-6
Molecular Formula	C₁₀H₁₂BrFO
Molecular Weight	247.11 g/mol
Synonyms	4-Fluoro-3-butoxybromobenzene; 3-Butoxy-4-fluorobromobenzene; 1-Bromo-3-butoxy-4-fluorobenzene; 4-Fluoro-3-n-butoxybromobenzene; 2-Bromo-5-fluorophenyl butyl ether; (3-Bromo-6-fluorophenoxy)butane; Butyl 3-bromo-4-fluorophenyl ether
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-n-Butyloxy-4-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment aligns with cGMP and ISO 9001 standards to guarantee consistency and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.