Description

2-Hydroxy-4-(Trifluoromethoxy)Phenylboronic Acid is a specialized organoboron compound featuring a phenolic hydroxyl group and a trifluoromethoxy substituent, making it a versatile building block for modern synthetic chemistry. Its primary value lies in its dual functionality, enabling it to act as both a boronic acid coupling partner and a hydrogen-bond donor or metal chelator in complex molecular assemblies. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for Suzuki-Miyaura cross-coupling reactions and the synthesis of bioactive molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for constructing biaryl scaffolds found in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that incorporate the trifluoromethoxy group for enhanced metabolic stability and bioavailability.
• Ligand for Catalysis: Serves as a component in designing novel ligands for transition metal catalysts due to its potential chelating properties.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as OLEDs and semiconductors, where the boronic acid group enables precise molecular assembly.
• Chemical Biology Probes: Utilized in the creation of molecular probes and sensors that target specific biological processes.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	2-Hydroxy-4-(Trifluoromethoxy)Phenylboronic Acid
CAS No.	1309768-22-6
Molecular Formula	C7H6BF3O4
Molecular Weight	221.93 g/mol
Synonyms	[2-Hydroxy-4-(trifluoromethoxy)phenyl]boronic acid; 2-Borono-4-(trifluoromethoxy)phenol; 4-(Trifluoromethoxy)salicylboronic acid; (2-Hydroxy-4-trifluoromethoxyphenyl)boronic acid; 2-Hydroxy-4-(trifluoromethoxy)benzeneboronic acid; 2-Hydroxy-4-(trifluoromethoxy)phenylboronic acid pinacol ester (protected form); B-[2-Hydroxy-4-(trifluoromethoxy)phenyl]boronic acid
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-4-(Trifluoromethoxy)Phenylboronic Acid is produced under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and consistent lot-to-lot performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.