Description

3-(2,2-Difluoroethoxy)Propionitrile is a specialized organic nitrile building block featuring a difluoroethoxy side chain, offering unique reactivity and physicochemical properties. This compound is valued for its role as a versatile intermediate in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially those requiring fluorinated ether motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of new generation herbicides, fungicides, and insecticides where the difluoroethoxy group can influence biological activity and environmental fate.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced materials with tailored surface properties.
• Liquid Crystal & Electronic Chemicals: Potential intermediate for creating fluorinated components used in liquid crystal displays (LCDs) and other electronic applications.
• Organic Synthesis Reagent: Employed in academic and industrial laboratories for constructing complex molecular architectures via cyano-group transformations (e.g., reduction to amines, hydrolysis to acids).

Basic Information

Product Name	3-(2,2-Difluoroethoxy)Propionitrile
CAS No.	1309602-19-4
Molecular Formula	C5H7F2NO
Molecular Weight	135.11 g/mol
Synonyms	3-(2,2-Difluoroethoxy)propanenitrile; 2,2-Difluoroethyl 2-cyanoethyl ether; Propionitrile, 3-(2,2-difluoroethoxy)-; 1309602-19-4; 3-(2,2-Difluoroethoxy)propiononitrile; 2-(2,2-Difluoroethoxy)ethyl cyanide; 3-(Difluoroethoxy)propionitrile
EINECS	Contact for details

Quality Control

Every batch of 3-(2,2-Difluoroethoxy)Propionitrile is produced and tested under a strict quality management system. We ensure high purity and consistency through advanced analytical techniques including GC, HPLC, and NMR. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee it meets your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature: 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.