Description

n-(2-Ethynyltetrahydro-2H-Pyran-4-Yl)Acetamide is a specialized organic building block featuring a unique molecular scaffold combining an acetamide group with a tetrahydro-2H-pyran ring and an ethynyl moiety. This compound matters as a high-value intermediate for advanced pharmaceutical research and fine chemical synthesis, enabling the construction of complex molecules with targeted biological activity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders or requiring complex heterocyclic architectures.
• Agrochemical Research: Used in developing new generation pesticides and herbicides, where its structural motifs can contribute to specific biological activity and environmental stability.
• Chemical Biology Probe Development: Serves as a precursor for creating molecular probes and tags, leveraging the reactive alkyne group for click chemistry applications like CuAAC (Copper-Catalyzed Azide-Alkyne Cycloaddition).
• Material Science Precursor: Potential monomer or cross-linking agent in the development of advanced polymers and resins with tailored thermal or mechanical properties.
• Academic & Contract Research: Essential reagent for methodological studies in organic synthesis and medicinal chemistry within university laboratories and CROs (Contract Research Organizations).
• Fine Chemical Synthesis: Intermediate for producing specialty chemicals, flavors, and fragrances requiring precise stereochemistry and functional group compatibility.

Basic Information

Product Name	n-(2-Ethynyltetrahydro-2H-Pyran-4-Yl)Acetamide
CAS No.	1309366-02-6
Molecular Formula	C9H13NO2
Molecular Weight	167.21 g/mol
Synonyms	N-(2-Ethynyloxan-4-yl)acetamide; 2-Ethynyltetrahydro-2H-pyran-4-amine, N-acetyl derivative; Acetamide, N-(2-ethynyltetrahydro-2H-pyran-4-yl)-; 4-Acetamidotetrahydro-2H-pyran-2-ylethyne; 1309366-02-6; 2-Ethynyl-N-(tetrahydro-2H-pyran-4-yl)acetamide (isomeric form); Building block 1309366-02-6
EINECS	Contact for details

Quality Control

Our n-(2-Ethynyltetrahydro-2H-Pyran-4-Yl)Acetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We can supply material tailored to various purity grades, including research grade and GMP-grade for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain stability. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95% (Research Grade)
Purity (HPLC)	≥98% (Premium Grade)
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.