Description

(R)-Atenolol-D7 CAS NO 1309283-25-7 is a high-purity, deuterium-labeled isotopologue of the β-blocker (R)-Atenolol, specifically designed for use as an internal standard in quantitative bioanalytical methods. This compound is critical for ensuring the accuracy and reliability of pharmacokinetic and metabolism studies by correcting for variations during sample preparation and analysis. It is an essential tool for pharmaceutical research and development, clinical laboratories, and contract research organizations (CROs) engaged in drug development and regulatory compliance testing.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, isotopically labeled internal standard for the precise quantification of (R)-Atenolol in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic (PK) Studies: Enables accurate measurement of drug absorption, distribution, metabolism, and excretion (ADME) profiles for the (R)-enantiomer of Atenolol.
• Metabolite Identification & Profiling: Used in mass spectrometry-based studies to track and identify metabolites, aiding in understanding the drug's metabolic pathways.
• Bioequivalence & Clinical Trials: Supports robust analytical methods required for bioequivalence studies and clinical trial sample analysis, ensuring data integrity for regulatory submissions.
• Forensic & Doping Analysis: Applicable in forensic toxicology and anti-doping controls for the specific and sensitive detection of (R)-Atenolol.
• Method Development & Validation: Serves as a critical component in developing, optimizing, and validating new analytical methods according to FDA, EMA, or ICH guidelines.

Basic Information

Product Name	(R)-Atenolol-D7
CAS No.	1309283-25-7
Molecular Formula	C14H15D7N2O3
Molecular Weight	273.36 g/mol (for deuterated form)
Synonyms	(R)-2-[4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]acetamide-D7; (R)-Atenolol-d7; (R)-4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide-D7; (R)-Atenolol (heptadeuterated); Atenolol-(ring-d4, isopropyl-d3); (R)-Isomer of Atenolol-D7; Deuterated (R)-Atenolol
EINECS	Contact for details

Quality Control

Our (R)-Atenolol-D7 is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity, essential for its role as an analytical standard. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chemical purity, isotopic enrichment, and chromatographic profile. We adhere to relevant industry guidelines for reference standards to ensure reliability in sensitive applications like LC-MS/MS.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.