Description

Desacetyl Diltiazem-D6 Hydrochloride is a high-purity, deuterium-labeled internal standard critical for accurate quantitative analysis in pharmaceutical research and development. This stable isotope-labeled compound is essential for ensuring precision and reliability in mass spectrometry-based assays, particularly for pharmacokinetic and metabolic studies. It is primarily utilized by analytical laboratories, CROs, and pharmaceutical companies engaged in the development and quality control of cardiovascular therapeutics.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the precise quantification of Diltiazem and its metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Facilitates accurate studies on the absorption, distribution, metabolism, and excretion (ADME) profile of Diltiazem.
• Bioanalytical Method Development and Validation: Serves as a critical reference material for developing and validating robust, GLP-compliant analytical methods.
• Clinical Research and Therapeutic Drug Monitoring (TDM): Enables reliable measurement of drug concentrations in patient samples during clinical trials and routine monitoring.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradants in active pharmaceutical ingredient (API) batches.
• Forensic and Toxicology Analysis: Supports accurate detection and quantification in forensic investigations related to drug exposure or overdose.

Basic Information

Product Name	Desacetyl Diltiazem-D6 Hydrochloride
CAS No.	1309283-22-4
Molecular Formula	C22H20D6N2O4S • HCl
Molecular Weight	467.02 g/mol (for monohydrochloride)
Synonyms	(2S,3S)-5-[2-(Dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate-D6 hydrochloride; Diltiazem Impurity C-D6 (Desacetyl Diltiazem-D6 HCl); Diltiazem Related Compound C-D6; 3-Acetoxy-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one-D6 hydrochloride; (+)-cis-3-Acetoxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one-D6 hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Desacetyl Diltiazem-D6 Hydrochloride is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and MS. A detailed Certificate of Analysis (COA) specifying purity, isotopic enrichment, and impurity profile is provided with each shipment to ensure compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms to structure
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.