Description

Phenoxybenzamine-D5 is a deuterated analog of the α-adrenergic blocking agent phenoxybenzamine, specifically labeled with five deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical results. It is a critical material for researchers and quality control laboratories in the pharmaceutical, forensic, and clinical diagnostics sectors who require precise measurement of phenoxybenzamine and its metabolites.

Application

• Primary use as an internal standard for the quantification of phenoxybenzamine in LC-MS/MS and GC-MS bioanalytical methods.
• Pharmacokinetic and metabolic studies in pharmaceutical research and development.
• Forensic and clinical toxicology analysis for accurate drug level determination.
• Quality control and method validation in pharmaceutical manufacturing.
• Supporting regulatory submissions requiring robust bioanalytical data.
• Use in environmental fate studies of pharmaceutical compounds (as a tracer).

Basic Information

Product Name	Phenoxybenzamine-D5
CAS No.	1309283-11-1
Molecular Formula	C18H17D5ClNO
Molecular Weight	303.85 g/mol (approx.)
Synonyms	Phenoxybenzamine-d5; N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine-d5; N-Benzyl-N-(2-chloroethyl)-1-phenoxy-2-propylamine-d5; Benzyl(2-chloroethyl)(1-methyl-2-phenoxyethyl)amine-d5; Dibenzyline-d5 (deuterated); SKF-688A-d5; NSC-115079-d5; (RS)-Phenoxybenzamine-d5
EINECS	Contact for details

Quality Control

Our Phenoxybenzamine-D5 is manufactured under strict quality control protocols to ensure exceptional isotopic purity and chemical stability, meeting the rigorous demands of analytical reference standards. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D5, typically >98 atom % D), chemical purity (by HPLC), and confirmatory structural data. We support compliance with GMP/GLP principles for research and regulatory applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D5)	≥98 atom % D
Chemical Purity (by HPLC)	≥95.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.