Description

Repaglinide Acyl-β-D-Glucuronide is a key metabolite of the anti-diabetic drug repaglinide, formed via glucuronidation. This compound is of critical importance for pharmaceutical research and development, specifically in the areas of drug metabolism and pharmacokinetic (DMPK) studies. It serves as a vital reference standard for analytical laboratories and R&D departments engaged in bioanalytical method development, metabolite identification, and regulatory safety assessments.

Application

• Pharmaceutical Reference Standard: Primary use as a certified standard for the quantification and identification of repaglinide metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK): Essential for studying the metabolic pathways, clearance mechanisms, and bioavailability of repaglinide.
• Bioanalytical Method Development: Used to validate HPLC, LC-MS, and LC-MS/MS methods for accurate metabolite profiling in preclinical and clinical studies.
• Toxicology and Safety Assessment: Supports investigations into the safety profile and potential toxicity of repaglinide metabolites.
• Impurity Profiling: Acts as a marker for impurity identification and control during the drug manufacturing process of repaglinide.
• Academic and Contract Research: Utilized in universities and CROs (Contract Research Organizations) for fundamental research on glucuronidation processes and drug-drug interactions.

Basic Information

Product Name	Repaglinide Acyl-β-D-Glucuronide
CAS No.	1309112-13-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Repaglinide Glucuronide; Repaglinide Acyl Glucuronide; Repaglinide Metabolite; 2-[[(1S)-1-Cyclohexyl-4-[[(1S,2S)-2-hydroxy-1-methylpropyl]amino]-4-oxobutyl]amino]benzoic acid β-D-Glucopyranosiduronic acid; (S)-2-(4-(Cyclohexyl((1S,2S)-2-hydroxy-1-methylpropyl)amino)-4-oxobutanamido)benzoic acid β-D-Glucuronide; AG-EE 388 ZW Glucuronide
EINECS	Contact for details

Quality Control

Our Repaglinide Acyl-β-D-Glucuronide is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical reference materials. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.