Description

Ethyl 2,2-Difluoro-2-(2-Nitrophenyl)Acetate is a specialized fluorinated organic building block of significant interest in advanced synthetic chemistry. Its core value lies in the unique combination of a difluoroacetate ester moiety and an ortho-nitrophenyl group, which enables precise molecular construction. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the fluorine atoms can enhance biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers and advanced organic materials with tailored properties.
• Fluorine Chemistry Studies: An important reagent for investigating new fluorination methodologies and the behavior of difluoromethylene groups in organic transformations.
• Ligand and Catalyst Development: The nitrophenyl group can be reduced to an aniline, facilitating its use in creating novel ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	Ethyl 2,2-Difluoro-2-(2-Nitrophenyl)Acetate
CAS No.	1308915-12-9
Molecular Formula	C10H9F2NO4
Molecular Weight	245.18 g/mol
Synonyms	Ethyl 2,2-Difluoro-2-(2-nitrophenyl)acetate; 2-Nitrobenzyl 2,2-Difluoroacetate; Ethyl (2-Nitrophenyl)difluoroacetate; 2,2-Difluoro-2-(2-nitrophenyl)acetic Acid Ethyl Ester; Acetic acid, 2,2-difluoro-2-(2-nitrophenyl)-, ethyl ester; Ethyl α,α-Difluoro-2-nitrobenzeneacetate; (2-Nitrophenyl)difluoroacetic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl 2,2-Difluoro-2-(2-Nitrophenyl)Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and batch-to-batch consistency suitable for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.