Description

Propargyl-Peg4-Bromide is a high-purity, functionalized polyethylene glycol (PEG) linker featuring a terminal propargyl group and a bromide handle, enabling versatile bioconjugation and click chemistry applications. This compound is essential for researchers and manufacturers requiring precise, modular construction of complex molecular architectures, such as antibody-drug conjugates (ADCs) and targeted therapeutics. It is particularly valuable for pharmaceutical R&D, materials science, and the development of diagnostic probes where controlled, site-specific labeling is critical.

Application

• Bioconjugation and ADC (Antibody-Drug Conjugate) Development: Serves as a heterobifunctional crosslinker for attaching cytotoxic payloads to monoclonal antibodies via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry.
• PEGylation and Linker Chemistry: Used to introduce hydrophilic PEG spacers to enhance the solubility, stability, and pharmacokinetic profiles of bioactive molecules.
• Polymer and Materials Science: Acts as a functional monomer or initiator in the synthesis of smart polymers, hydrogels, and surface coatings with tailored properties.
• Diagnostic Probe Synthesis: Facilitates the creation of fluorescent, radioactive, or other tagged molecular probes for imaging and detection assays.
• Chemical Biology Tool Development: Enables the site-specific labeling of proteins, peptides, and nucleic acids for studying biological interactions and pathways.
• Nanoparticle Functionalization: Used to modify the surface of nanoparticles (e.g., liposomes, dendrimers) for targeted drug delivery systems.

Basic Information

Product Name	Propargyl-Peg4-Bromide
CAS No.	1308299-09-3
Molecular Formula	C15H27BrO4
Molecular Weight	351.28 g/mol
Synonyms	1-Bromo-2,5,8,11-tetraoxatetradec-13-yne; Propargyl-PEG4-Br; 3-((2-(2-(2-(2-Bromoethoxy)ethoxy)ethoxy)ethoxy)prop-1-yne; 13-Propargyl-3,6,9,12-tetraoxa-1-bromotetradecane; Propargyl tetraethylene glycol bromide; Br-PEG4-Propargyl; PEG4-Propargyl Bromide; 2,5,8,11-Tetraoxatetradec-13-yn-1-yl bromide
EINECS	Contact for details

Quality Control

Our Propargyl-Peg4-Bromide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and pharmaceutical applications. Each lot is characterized by NMR, HPLC, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) detailing all relevant specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep the container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.