Description

[2H8]-Didesmethylcariprazine is a deuterated analog of a key metabolite of the antipsychotic drug cariprazine. This stable isotope-labeled compound is essential for advanced pharmacokinetic and metabolic studies, providing critical internal standards for mass spectrometry. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug development and bioanalytical method validation.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference in the bioanalysis of cariprazine and its metabolites in biological matrices like plasma and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracer studies to elucidate the metabolic pathways and clearance mechanisms of cariprazine.
• Clinical Trial Support: Enables accurate and reliable measurement of drug concentration levels during preclinical and clinical phases of development.
• Method Development and Validation: Aids in the establishment of robust, sensitive, and specific analytical methods compliant with FDA and ICH guidelines.
• Reference Material for Impurity Profiling: Can be used as a certified reference material to identify and quantify related substances in active pharmaceutical ingredient (API) batches.

Basic Information

Item	Detail
Product Name	[2H8]-Didesmethylcariprazine
CAS No.	1308279-08-4
Molecular Formula	C21H26D8ClN3O
Molecular Weight	Contact for details
Synonyms	Deuterated Didesmethyl Cariprazine; Cariprazine-d8 Metabolite; 3-[[4-(2,3-Dichlorophenyl)piperazin-1-yl]methyl]-1-(2,2,3,3,4,4,5,5-octadeuteriopentyl)pyrrolidine-2,5-dione; RGH-188 Metabolite-d8; UNII-Contact for details
EINECS	Contact for details

Quality Control

Every batch of [2H8]-Didesmethylcariprazine is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to support its use in regulated environments, including deuterium enrichment (D%) and chemical purity verified by NMR, HPLC, and MS. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the product at -20°C under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Enrichment (D%)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.