Description

Cariprazine-D6 is a deuterium-labeled analog of the antipsychotic drug Cariprazine, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity reference material is essential for ensuring accuracy and reliability in pharmacokinetic, metabolic, and bioanalytical studies. It is primarily used by pharmaceutical researchers, analytical laboratories, and contract research organizations (CROs) involved in drug development and quality control.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of Cariprazine in biological matrices (e.g., plasma, serum, urine) using liquid chromatography-tandem mass spectrometry.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to track the absorption, distribution, metabolism, and excretion (ADME) profile of Cariprazine in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Serves as a stable isotope-labeled standard to improve method accuracy, precision, and to compensate for matrix effects and instrument variability.
• Pharmaceutical Quality Control: Employed in the analysis of drug substances and finished products to ensure potency and purity.
• Forensic and Clinical Toxicology: Aids in the accurate detection and measurement of Cariprazine levels in forensic or therapeutic drug monitoring scenarios.

Basic Information

Product Name	Cariprazine-D6
CAS No.	1308278-67-2
Molecular Formula	C26H26D6Cl2N4O
Molecular Weight	473.46 g/mol
Synonyms	Deuterated Cariprazine; Cariprazine (hexadeuterated); RGH-188-D6; trans-N-{4-[2-[4-(2,3-Dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl}-N',N'-dimethyl-D6-urea; UNII-1XH5U26K4H (deuterated); 1-[trans-4-[2-[4-(2,3-Dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-N,N-dimethyl-D6-urea
EINECS	Contact for details

Quality Control

Our Cariprazine-D6 is manufactured under strict quality systems to ensure the highest standards of purity and isotopic enrichment required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results from NMR (¹H, ¹³C), HPLC, and mass spectrometry analyses. We adhere to relevant industry guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or Certificate of Analysis. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.