Description

2,2-Difluoro-4-Methylenepentanedioic Acid Diethyl Ester is a high-value fluorinated building block and diester compound. This specialty chemical is critical for introducing difluoromethylene and ester functionalities into complex molecular architectures, enabling precise tuning of physical and chemical properties. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for constructing fluorinated analogs of drug candidates, potentially enhancing metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the difluoromethylene group can improve efficacy and environmental profile.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers and coatings with unique surface properties and chemical resistance.
• Ligand and Catalyst Development: Employed in organic and organometallic chemistry to create novel chelating agents or catalyst frameworks.
• Fluorine Chemistry Research: An essential reagent for academic and industrial research exploring new C-F bond formation reactions and fluorination methodologies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke fluorinated compounds for client-specific projects.

Basic Information

Product Name	2,2-Difluoro-4-Methylenepentanedioic Acid Diethyl Ester
CAS No.	1307857-46-0
Molecular Formula	C11H16F2O4
Molecular Weight	250.24 g/mol
Synonyms	Diethyl 2,2-Difluoro-4-methylenepentanedioate; 4-Methylene-2,2-difluoropentanedioic Acid Diethyl Ester; Pentanedioic acid, 2,2-difluoro-4-methylene-, diethyl ester; Difluoromethylenesuccinic Acid Diethyl Ester Derivative
EINECS	Contact for details

Quality Control

Every batch of 2,2-Difluoro-4-Methylenepentanedioic Acid Diethyl Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) specifying identity, purity (typically by GC/HPLC), and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.