Description

2,2-Difluoro-4-Methylenepentanedioic Acid is a specialized fluorinated dicarboxylic acid derivative, serving as a high-value synthetic intermediate. Its unique structure, featuring both difluoro and exocyclic methylene groups, makes it a critical building block for introducing fluorinated motifs into complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, where precise fluorination is required to modulate the biological activity, metabolic stability, and physicochemical properties of target compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for drugs targeting metabolic and central nervous system disorders.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the fluorine atoms enhance lipophilicity and environmental stability.
• Material Science Research: Serves as a monomer or cross-linking agent for creating specialty polymers with unique surface properties and chemical resistance.
• Fluorinated Building Block: Employed in medicinal chemistry for the late-stage functionalization and diversification of compound libraries via its reactive carboxylic acid and alkene groups.
• Ligand and Catalyst Development: Useful in organometallic chemistry for constructing chelating ligands that can form complexes with metals for catalytic applications.
• Chemical Biology Probes: Acts as a scaffold for developing activity-based probes and diagnostic agents that exploit fluorine for 19F NMR or PET imaging.

Basic Information

Product Name	2,2-Difluoro-4-Methylenepentanedioic Acid
CAS No.	1307857-45-9
Molecular Formula	C7H8F2O4
Molecular Weight	194.13 g/mol
Synonyms	4-Methylene-2,2-difluoropentanedioic Acid; 2,2-Difluoro-4-methyleneglutaric Acid; Difluoromethylenepentanedioic Acid Derivative; 4-Methylenepentanedioic Acid, 2,2-difluoro-; (4-Methylene-2,2-difluoropentanedioic Acid); Glutaric acid, 2,2-difluoro-4-methylene-
EINECS	Contact for details

Quality Control

Every batch of 2,2-Difluoro-4-Methylenepentanedioic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, NMR, and other relevant spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.