Description

(1R)-1-Hydroxy-2,3-Dihydro-1H-Indene-4-Carbonitrile is a chiral, high-purity organic intermediate of significant importance in modern synthetic chemistry. Its value lies in its unique indane-based scaffold and functional groups, making it a versatile building block for the creation of complex, stereochemically defined molecules. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potential drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Investigated as a monomer or additive for specialty polymers and liquid crystals due to its rigid, fused-ring structure.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies and the exploration of new chemical spaces.

Basic Information

Product Name	(1R)-1-Hydroxy-2,3-Dihydro-1H-Indene-4-Carbonitrile
CAS No.	1306763-24-5
Molecular Formula	C10H9NO
Molecular Weight	159.19 g/mol
Synonyms	(1R)-4-Cyano-2,3-dihydro-1H-inden-1-ol; (R)-1-Hydroxy-2,3-dihydro-1H-indene-4-carbonitrile; (R)-4-Cyanoindan-1-ol; (1R)-1-Hydroxyindane-4-carbonitrile; (R)-1-Hydroxy-4-cyanoindane; 4-Cyano-(1R)-indanol; (R)-1-Indanol-4-carbonitrile
EINECS	Contact for details

Quality Control

Every batch of (1R)-1-Hydroxy-2,3-Dihydro-1H-Indene-4-Carbonitrile is manufactured under strict quality management systems. We employ advanced analytical techniques, including chiral HPLC, to guarantee high enantiomeric purity and chemical identity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original sealed packaging to prevent degradation. Allow the container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.