Description

Riociguat 13Cd6 is a stable isotope-labeled analog of the pharmaceutical compound Riociguat, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity reference material is essential for ensuring the accuracy and reliability of mass spectrometry-based analyses in pharmaceutical research and development. It is primarily utilized by analytical chemists and quality control laboratories in the pharmaceutical and contract research organization (CRO) sectors for pharmacokinetic studies, bioanalytical method validation, and impurity profiling.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard for the precise quantification of Riociguat and its metabolites in complex biological matrices such as plasma, serum, and urine.
• Bioanalytical Method Development & Validation: Used in the development and validation of robust, GLP-compliant analytical methods for clinical and non-clinical studies.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in study subjects.
• Metabolite Identification and Profiling: Aids in the identification and quantification of drug metabolites using high-resolution mass spectrometry.
• Quality Control and Stability Testing: Employed in pharmaceutical QC labs to monitor the stability and consistency of drug substance and product batches.
• Doping Control Analysis: Potential application in forensic and sports anti-doping laboratories for the detection of Riociguat.

Basic Information

Product Name	Riociguat 13Cd6
CAS No.	1304478-43-0
Molecular Formula	C20H19D6FN6O3
Molecular Weight	422.48 g/mol
Synonyms	Riociguat-d6; BAY 63-2521-d6; 1-Methyl-3-(4,6-diamino-2,5-dihydro-1,3,5-triazin-2-yl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid (methyl-d3)-2-oxy-4-(phenyl-d3)butyl ester; 4-({(4-Carboxy-1-methyl-1H-pyrazolo[3,4-b]pyridin-3-yl)(diamino)methylene}amino)-2-(methoxy-d3)-1-(phenyl-d3)butyl methanesulfonate; Adempas-d6 (labeled analog)
EINECS	Contact for details

Quality Control

Every batch of Riociguat 13Cd6 is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data for isotopic purity, chemical purity, and identity confirmation. Our quality protocols are designed to meet the stringent requirements of pharmaceutical reference standard applications, ensuring data integrity for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 99.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.