Description

D-Proline, 4,4-Dimethyl- is a high-purity, non-natural amino acid derivative characterized by its unique stereochemistry and dimethyl substitution on the proline ring. This compound is a critical chiral building block and intermediate in advanced organic synthesis, offering significant value in the development of pharmaceuticals and bioactive molecules. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for applications requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other therapeutic agents.
• Peptide Chemistry: Used in the design and synthesis of constrained peptides to influence secondary structure, stability, and biological activity.
• Asymmetric Catalysis: Acts as a precursor or ligand for chiral catalysts and auxiliaries in enantioselective synthesis.
• Agrochemical Research: Employed in the development of new herbicides, fungicides, and plant growth regulators with specific stereochemical requirements.
• Biochemical Research: Utilized as a tool compound in enzymatic studies and for probing protein structure-function relationships.
• Material Science: Investigated for the creation of novel chiral polymers and functional materials.

Basic Information

Product Name	D-Proline, 4,4-Dimethyl-
CAS No.	1303975-05-4
Molecular Formula	C7H13NO2
Molecular Weight	143.18 g/mol
Synonyms	(2R)-4,4-Dimethylpyrrolidine-2-carboxylic acid; D-4,4-Dimethylproline; (R)-4,4-Dimethylproline; 4,4-Dimethyl-D-proline; D-4,4-Dimethyl-2-pyrrolidinecarboxylic acid; (R)-4,4-Dimethyl-2-pyrrolidinecarboxylic acid
EINECS	Contact for details

Quality Control

Our D-Proline, 4,4-Dimethyl- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and industrial synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.