Description

3-(Trifluoromethylsulfonyl)Phenylacetic Acid is a high-value, multi-functional organic building block characterized by its phenylacetic acid core and a potent trifluoromethylsulfonyl substituent. This compound matters for its unique combination of acidity and the electron-withdrawing, lipophilic properties of the trifluoromethanesulfonyl group, making it an essential intermediate in advanced synthetic chemistry. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, especially those targeting metabolic and inflammatory pathways.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and fungicides, leveraging its bioisosteric properties.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced polymers and organic electronic materials due to its electron-deficient aromatic system.
• Chemical Biology Probes: Utilized as a building block for developing activity-based probes and enzyme inhibitors in proteomics research.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses serving the fine chemical and life science sectors.

Basic Information

Product Name	3-(Trifluoromethylsulfonyl)Phenylacetic Acid
CAS No.	1301739-14-9
Molecular Formula	C9H7F3O4S
Molecular Weight	268.21 g/mol
Synonyms	[3-(Trifluoromethyl)sulfonyl]phenylacetic Acid; 2-[3-(Trifluoromethyl)sulfonylphenyl]acetic Acid; α-(3-((Trifluoromethyl)sulfonyl)phenyl)acetic Acid; m-(Trifluoromethylsulfonyl)phenylacetic Acid; 3-(Trifluoromethanesulfonyl)phenylacetic Acid; 3-(TFS)phenylacetic Acid; 3-(Triflyl)phenylacetic Acid
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethylsulfonyl)Phenylacetic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.