Description

2-(Difluoromethoxy)Pyridin-3-Ylboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to develop novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing pyridine-containing drug candidates with difluoromethoxy substituents.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides that require specific heterocyclic frameworks for enhanced activity and selectivity.
• Material Science Research: Serves as a monomer or building block for developing organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.
• Academic & R&D Laboratories: Fundamental reagent for methodological development in cross-coupling chemistry and the exploration of new chemical space in medicinal chemistry programs.

Basic Information

Product Name	2-(Difluoromethoxy)Pyridin-3-Ylboronic Acid
CAS No.	1300750-50-8
Molecular Formula	C7H6BF2NO3
Molecular Weight	200.94 g/mol
Synonyms	2-(Difluoromethoxy)-3-pyridineboronic acid; [2-(Difluoromethoxy)pyridin-3-yl]boronic acid; 3-Borono-2-(difluoromethoxy)pyridine; 2-(Difluoromethoxy)-3-pyridinylboronic acid; Boronic acid, B-[2-(difluoromethoxy)-3-pyridinyl]-; 1300750-50-8; 2-Difluoromethoxypyridine-3-boronic acid
EINECS	Contact for details

Quality Control

Every batch of 2-(Difluoromethoxy)Pyridin-3-Ylboronic Acid is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive cross-coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our quality commitment supports compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) for long-term storage and to prevent degradation during use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.