Description

3-[(1R,2R)-1-Ethyl-2-Methyl-3-(Methylamino)Propyl]Phenyl β-D-Glucopyranosiduronic Acid is a sophisticated chiral glucuronide metabolite, representing a high-value intermediate in advanced pharmaceutical research and development. This compound is of critical importance for its role in drug metabolism and pharmacokinetic (DMPK) studies, enabling the precise analysis of metabolic pathways and the development of safer, more effective therapeutics. It is primarily sought after by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the synthesis and characterization of active pharmaceutical ingredients (APIs) and their metabolites.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantification and identification of drug metabolites in bioanalytical assays (LC-MS/MS, HPLC).
• Drug Metabolism and Pharmacokinetics (DMPK): A critical tool for studying Phase II metabolism via glucuronidation, aiding in the assessment of drug clearance, bioavailability, and potential drug-drug interactions.
• Preclinical and Clinical Research: Used in the development and validation of analytical methods for metabolite profiling in biological matrices during drug development stages.
• Impurity Characterization: Employed to identify and quantify glucuronide-related impurities in active pharmaceutical ingredient (API) batches to ensure purity and safety.
• Toxicology Studies: Facilitates the investigation of metabolite formation and its potential role in the toxicity profile of new chemical entities.
• Synthetic Intermediate: Acts as a key chiral building block for the custom synthesis of more complex drug metabolites or labeled analogs for tracer studies.

Basic Information

Product Name	3-[(1R,2R)-1-Ethyl-2-Methyl-3-(Methylamino)Propyl]Phenyl β-D-Glucopyranosiduronic Acid
CAS No.	1300037-84-6
Molecular Formula	C19H29NO7
Molecular Weight	383.44 g/mol
Synonyms	(1R,2R)-1-Ethyl-2-methyl-3-(methylamino)propyl phenyl β-D-glucopyranosiduronic acid; Phenyl β-D-glucuronide derivative; Drug metabolite glucuronide; Chiral glucuronide conjugate; 3-[(1R,2R)-1-Ethyl-2-methyl-3-(methylamino)propyl]phenyl β-D-glucuronide; β-Glucuronidase substrate analog; O-Glucuronide of substituted phenylpropanolamine derivative
EINECS	Contact for details

Quality Control

Every batch of 3-[(1R,2R)-1-Ethyl-2-Methyl-3-(Methylamino)Propyl]Phenyl β-D-Glucopyranosiduronic Acid is manufactured and controlled under a strict quality management system. Our products undergo rigorous quality testing to ensure identity, purity, and consistency, meeting the exacting standards required for research and development. Comprehensive analytical data, including HPLC purity, chiral purity, and structural confirmation (NMR, MS), is documented. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.