Description

Iloperidone (Hydrochloride) is the hydrochloride salt form of iloperidone, a second-generation atypical antipsychotic. This high-purity pharmaceutical intermediate is critical for the synthesis of the final active pharmaceutical ingredient (API) used in the treatment of schizophrenia. It is primarily required by pharmaceutical manufacturers and advanced research institutions engaged in neuropsychiatric drug development and production. Consistent quality and reliable supply are paramount for ensuring the efficacy and safety of the final medicinal product.

Application

• Pharmaceutical Active Ingredient (API) Synthesis: Primary use as a key intermediate in the commercial manufacturing of Iloperidone API.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical labs.
• Preclinical & Clinical Research: Used in pharmacological studies and formulation development for novel antipsychotic therapies.
• Process Development & Scale-up: Essential for chemical process optimization and pilot-scale production in R&D settings.
• Generic Drug Manufacturing: A critical starting material for companies producing generic versions of iloperidone-based medications.

Basic Information

Product Name	Iloperidone (Hydrochloride)
CAS No.	1299470-39-5
Molecular Formula	C24H27FN2O4 • HCl
Molecular Weight	462.94 g/mol (as hydrochloride salt)
Synonyms	Iloperidone HCl; Iloperidone Hydrochloride; 1-[4-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3-methoxyphenyl]ethanone Hydrochloride; Fanapta Hydrochloride (trade name related); 4'-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3'-methoxyacetophenone Hydrochloride; Zomaril Hydrochloride (trade name related); HP 873 Hydrochloride
EINECS	Contact for details

Quality Control

Our Iloperidone (Hydrochloride) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identification by IR and NMR, and stringent control of related substances and residual solvents, to ensure it meets exacting pharmaceutical standards. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.