Description

(R)-n-((3-Methylpyridin-2-Yl)Methyl)-7′-Di(3,5-Di-tert-Butylphenyl)Phosphino-1,1′-Spirobiindanyl-7-Amine CAS NO 1298133-36-4 is a sophisticated chiral phosphine ligand designed for high-performance asymmetric catalysis. This compound matters because it enables the precise control of stereochemistry in critical chemical transformations, leading to higher yields and enantiomeric purity of target molecules. It is primarily needed by research institutions and pharmaceutical manufacturers developing novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• As a key chiral ligand in asymmetric hydrogenation reactions for pharmaceutical intermediate synthesis.
• Catalyst component in asymmetric C-C bond formation processes, such as cross-coupling and allylic substitution.
• Enabling technology for the stereoselective synthesis of complex natural products and agrochemicals.
• Use in academic and industrial R&D for developing new catalytic methodologies.
• Potential application in the production of chiral amines and alcohols, which are ubiquitous building blocks in medicinal chemistry.
• Supporting process chemistry for the scale-up and optimization of enantiomerically pure compounds.

Basic Information

Product Name	(R)-n-((3-Methylpyridin-2-Yl)Methyl)-7′-Di(3,5-Di-tert-Butylphenyl)Phosphino-1,1′-Spirobiindanyl-7-Amine
CAS No.	1298133-36-4
Molecular Formula	C55H66N2P
Molecular Weight	785.09 g/mol
Synonyms	(R)-DTBM-SEGPHOS; (R)-7,7′-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-2,2′,3,3′-tetrahydro-1,1′-spirobi[indene]; (R)-3,3′,5,5′-Tetra-tert-butyl-2,2′-dimethoxy-7,7′-bis(diphenylphosphino)-1,1′-spirobi[indene] (common misnomer for related ligands); (R)-DTBM-SEGPHOS ligand; (R)-SEGPHOS derivative with tert-butyl groups; Chiral biaryl diphosphine ligand; Asymmetric hydrogenation ligand CAS 1298133-36-4
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized by advanced analytical techniques including NMR, HPLC, and elemental analysis to confirm identity, chiral purity, and chemical purity. Certificates of Analysis (COA) are available upon request, detailing all relevant specifications to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to prevent oxidation and degradation. Keep the container in a dry, cool, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.