Description

(2R)-1-(1,1,1,2,3,3,3-Heptadeuteriopropan-2-Ylamino)-3-[4-(2-Methoxyethyl)Phenoxy]Propan-2-Ol CAS NO 1292907-84-6 is a deuterated derivative of a β-adrenergic receptor antagonist, specifically a deuterated analog of propranolol or a related compound. This high-purity, isotopically labeled compound is critical for advanced research and development, particularly in pharmacokinetic and metabolic studies where tracking molecular pathways is essential. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on drug discovery, analytical method development, and deuterium-based chemical synthesis.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical, non-interfering reference standard for the precise quantification of its non-deuterated counterpart in complex biological matrices like plasma and tissue homogenates.
• Metabolic Pathway Tracing (Stable Isotope Labeling): Used in Absorption, Distribution, Metabolism, and Excretion (ADME) studies to elucidate metabolic profiles and identify metabolites using mass spectrometry.
• Deuterated Pharmaceutical Intermediate: Acts as a key building block in the synthesis of more complex deuterated drug candidates, leveraging the kinetic isotope effect for potential improved metabolic stability.
• Pharmacokinetic (PK) and Bioavailability Research: Enables accurate and reliable measurement of drug concentration over time due to its nearly identical chemical properties with superior mass spectrometric differentiation.
• Analytical Method Development and Validation: Essential for developing robust, sensitive, and specific bioanalytical assays in compliance with regulatory guidelines (e.g., FDA, EMA).
• Mechanistic Biochemical Studies: Facilitates research into β-adrenergic receptor interactions and signaling pathways using isotopically labeled probes.

Basic Information

Product Name	(2R)-1-(1,1,1,2,3,3,3-Heptadeuteriopropan-2-Ylamino)-3-[4-(2-Methoxyethyl)Phenoxy]Propan-2-Ol
CAS No.	1292907-84-6
Molecular Formula	C15H18D7NO3
Molecular Weight	Approx. 280.4 g/mol
Synonyms	1-(1,1,1,2,3,3,3-Heptadeuterio-2-propanyl)-3-[4-(2-methoxyethyl)phenoxy]-2-propanol, (2R)-; Deuterated Propranolol Derivative; (R)-1-(Heptadeuterioisopropylamino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol; D7-Propranolol Analog; Isotopically Labeled β-Blocker Intermediate; (2R)-D7-Isopropylamino-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol; 1292907-84-6
EINECS	Contact for details

Quality Control

Every batch of (2R)-1-(1,1,1,2,3,3,3-Heptadeuteriopropan-2-Ylamino)-3-[4-(2-Methoxyethyl)Phenoxy]Propan-2-Ol is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectrometric techniques, to ensure compliance with exacting standards for isotopic purity and chemical purity. Certificates of Analysis (COA) detailing batch-specific results for assay, isotopic enrichment, and impurities are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content, MS)	≥ 98 atom % D
Chemical Purity (Titration/NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.