Description

Tranexamic Acid 13C2 15N is a stable isotope-labeled analog of the antifibrinolytic agent Tranexamic Acid, specifically labeled with two carbon-13 atoms and one nitrogen-15 atom. This compound is an essential internal standard for the accurate quantification and pharmacokinetic profiling of Tranexamic Acid in biological matrices using advanced analytical techniques like LC-MS/MS. It is a critical material for pharmaceutical R&D, clinical research laboratories, and forensic toxicology units engaged in method development and validation.

Application

• Internal Standard for Bioanalysis: Primary use as a stable isotope-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the precise quantification of Tranexamic Acid in plasma, serum, and other biological fluids.
• Pharmacokinetic and Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Method Development and Validation: Critical for developing and validating robust, regulatory-compliant analytical methods in pharmaceutical quality control and research laboratories.
• Forensic and Clinical Toxicology: Used in assays to determine Tranexamic Acid concentrations in cases of overdose or therapeutic drug monitoring.
• Isotope Dilution Mass Spectrometry (IDMS): Serves as the labeled spike in IDMS, the gold-standard technique for achieving high accuracy and minimizing matrix effects in complex samples.
• Reference Material for Certified Standards: Acts as a key component in the preparation of certified reference materials (CRMs) for calibration and quality assurance programs.

Basic Information

Product Name	Tranexamic Acid 13C2 15N
CAS No.	1292837-95-6
Molecular Formula	C132C6H15N15NO2
Molecular Weight	160.18 g/mol (labeled)
Synonyms	trans-4-(Aminomethyl)cyclohexanecarboxylic-13C2,15N Acid; (1r,4r)-4-(Aminomethyl)cyclohexane-1-carboxylic-13C2,15N Acid; AMCHA-13C2,15N; TXA-13C2,15N; Cyclokapron-13C2,15N; Isotopically Labeled Tranexamic Acid; [13C2,15N]-Tranexamic Acid
EINECS	Contact for details

Quality Control

Our Tranexamic Acid 13C2 15N is manufactured under strict quality management systems. Each batch is characterized and tested to ensure high chemical purity, isotopic enrichment, and radiochemical purity. Comprehensive analytical data, including NMR and Mass Spectrometry, is generated to confirm structure and isotopic labeling. Certificates of Analysis (COA) detailing batch-specific results for identity, purity, and isotopic abundance are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to labeled mass
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C; ≥ 99 atom % 15N
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.